Daniel Levey

Work

Yale University

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Assistant Professor

US

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VA Connecticut Healthcare System

US

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Yale University School of Medicine

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Associate Research Scientist

US

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Yale University

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Postdoc

US

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Education

Indiana University School of Medicine

United States of America
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PhD. Major: Medical Neuroscience Minor: Cancer Biology

Publications

A contextual genomic perspective on physical activity and its relationship to health, well-being and illness

preprint

Genetics of SSRI Antidepressant Use and Relationship to Psychiatric and Medical Traits

preprint

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies.

Cell

journal-article

A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies

preprint

Genetics of Depression

Charney and Nestler's Neurobiology of Mental Illness

book-chapter

Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology

Psychological Medicine

journal-article

Integrating HiTOP and RDoC frameworks part II: shared and distinct biological mechanisms of externalizing and internalizing psychopathology

Psychological Medicine

journal-article

A contextual genomic perspective on physical activity and its relationship to health, well being and illness

Nature Genetics

journal-article

Multi-ancestry genetic architecture of sleep duration and its relationship to other sleep and psychiatric phenotypes

preprint

The Genetics of Fibromyalgia and its Relationships to Psychiatric and Medical Traits

preprint

Epigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses

Molecular Psychiatry

journal-article

Integrating HiTOP and RDoC Frameworks Part II: Shared and Distinct Biological Mechanisms of Externalizing and Internalizing Psychopathology

preprint

Shared genetics of ADHD, cannabis use disorder and cannabis use and prediction of cannabis use disorder in ADHD

Nature Mental Health

journal-article

Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders

Molecular Psychiatry

journal-article

Genome-wide association study of the common retinal disorder epiretinal membrane: Significant risk loci in each of three American populations

Cell Genomics

journal-article

Association between psoriasis and obsessive-compulsive disorder: a case-control study in the All of Us research program.

Archives of dermatological research

journal-article

Alcohol use and risk of dementia in diverse populations

preprint

Dissecting the Relationships Between Cannabis Use Disorder and Schizophrenia Using Genome-Wide Approaches

Biological Psychiatry

journal-article

Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.

Nature genetics

journal-article

Integrating HiTOP and RDoC Frameworks Part I: Genetic Architecture of Externalizing and Internalizing Psychopathology

preprint

A Multivariate Genome-Wide Association Study Reveals Neural Correlates and Common Biological Mechanisms of Psychopathology Spectra

preprint

Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depression

Nature Communications

journal-article

Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

Nature Genetics

journal-article

Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking

preprint

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology

preprint

Gene × environment effects and mediation involving adverse childhood events, mood and anxiety disorders, and substance dependence

Nature Human Behaviour

journal-article

Opioid use disorder and brain health: observational and genetic associations

preprint

Examining Methylation at the Intersection of Genetic Risk To Alzheimer’s Disease And Alcohol Use Disorder

Alzheimer's & Dementia

journal-article

Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction

Nature Communications

journal-article

Epigenetic and Genetic Profiling of Comorbidity Patterns among Substance Dependence Diagnoses

preprint

Polygenic liability for anxiety in association with comorbid anxiety in multiple sclerosis

Annals of Clinical and Translational Neurology

journal-article

54712 Bipolar disorder among patients with atopic dermatitis: A case-control study in the All of Us research program

Journal of the American Academy of Dermatology

journal-article

Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits

Molecular Psychiatry

journal-article

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology

Nature Human Behaviour

journal-article

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program

Science

journal-article

Shared genetics of ADHD, cannabis use disorder and cannabis use and prediction of cannabis use disorder in ADHD

Nature Mental Health

journal-article

Obsessive–compulsive disorder among patients with atopic dermatitis: a case–control study in the All of Us research program

Archives of Dermatological Research

journal-article

Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications

Nature Genetics

journal-article

Loneliness and depression: bidirectional mendelian randomization analyses using data from three large genome-wide association studies

Molecular Psychiatry

journal-article

Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration

Nature Communications

journal-article

Association between cannabis use and brain imaging phenotypes in UK Biobank: an observational and Mendelian randomization study

preprint

Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses

Nature Medicine

journal-article

Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs

Molecular Psychiatry

journal-article

Genomewide association study of epiretinal membrane: discovery of significant risk loci in each of three American populations

preprint

Exploring the genetic overlap between twelve psychiatric disorders

Nature Genetics

journal-article

Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathology

Nature Communications

journal-article

Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells

Nature Communications

journal-article

Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol’s effects

Molecular Psychiatry

journal-article

Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci

Molecular Psychiatry

journal-article

Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records

Molecular Psychiatry

journal-article

Genome-wide association study investigating short and long sleep duration: a cross-population meta-analysis

preprint

Identification of 64 new risk loci for major depression, refinement of the genetic architecture and risk prediction of recurrence and comorbidities

preprint

Multi-ancestry GWAS of major depression aids locus discovery, fine-mapping, gene prioritisation, and causal inference

preprint

Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analyses

PLOS Medicine

journal-article

Genome-wide investigation of maximum habitual alcohol intake (MaxAlc) in 247,755 European and African Ancestry U.S. Veterans informs the relationship between habitual alcohol consumption and alcohol use disorder

preprint

Exploring the genetic overlap between 12 psychiatric disorders

preprint

Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder

Molecular Psychiatry

journal-article

Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records

preprint

Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits

Molecular Psychiatry

journal-article

Impact of moderate alcohol consumption on brain iron and cognition: observational and genetic analyses

preprint

Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans

Molecular Psychiatry

journal-article

Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality.

Neurobiology of stress

journal-article

Genome-wide association study and multi-trait analysis of opioid use disorder identifies novel associations in 639,709 individuals of European and African ancestry

preprint

Genetic contributions to anxiety disorders: where we are and where we are heading

Psychological Medicine

journal-article

Alcohol consumption and telomere length: observational and Mendelian randomization approaches

other

Genetic variants associated with cross-disorder and disorder-specific risk for psychiatric disorders are enriched at epigenetically active sites in peripheral lymphoid cells

preprint

Comorbid-phenome prediction and phenotype risk scores enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder

other

Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs

Molecular Psychiatry

journal-article

Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions

Nature Neuroscience

journal-article

Dissecting Biological Pathways of Psychopathology using Cognitive Genomics

preprint

Genomics of Gulf War Illness in U.S. Veterans Who Served during the 1990-1991 Persian Gulf War: Methods and Rationale for Veterans Affairs Cooperative Study #2006.

Brain sciences

journal-article

Pleiotropic effects of telomere length loci with brain morphology and brain tissue expression.

Human molecular genetics

journal-article

Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder.

Psychological medicine

journal-article

Whole exome sequencing in the UK Biobank reveals risk gene SLC2A1 and biological insights for major depressive disorder

other

Dissecting the heterogeneity of posttraumatic stress disorder: differences in polygenic risk, stress exposures, and course of PTSD subtypes.

Psychological medicine

journal-article

Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program

Nature Genetics

journal-article

Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality

Translational Psychiatry

journal-article

Complex multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidal behaviors

preprint

Genome-wide meta-analysis of insomnia in over 2.3 million individuals implicates involvement of specific biological pathways through gene-prioritization

other

Trauma and posttraumatic stress interact with sex-specific risk loci for suicidality and converge on brain extracellular matrix biology and synaptic plasticity

other

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

preprint

Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder

other

Shared loci of telomere length with brain morphology, and pleiotropy in transcriptomic and epigenomic profiles of brain

other

Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits

Nature Neuroscience

journal-article

GWAS of Depression Phenotypes in the Million Veteran Program and Meta-analysis in More than 1.2 Million Participants Yields 178 Independent Risk Loci

other

Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program

American Journal of Psychiatry

journal-article

Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs

Molecular Psychiatry

journal-article

Reproducible Risk Loci and Psychiatric Comorbidities in Anxiety: Results from ~200,000 Million Veteran Program Participants

other

Reproducible Risk Loci and Psychiatric Comorbidities in Anxiety: Results from ~200,000 Million Veteran Program Participants

other

Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs.

Molecular psychiatry

journal-article

Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs

Molecular Psychiatry

journal-article

Genetic associations with suicide attempt severity and genetic overlap with major depression.

Translational psychiatry

journal-article

Genetic associations with suicide attempt severity and genetic overlap with major depression

Translational Psychiatry

journal-article

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Nature Communications

journal-article

Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci

Biological Psychiatry

journal-article

Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci

Biological Psychiatry

journal-article

Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran Sample

preprint

Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

bioRxiv

preprint

Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study

Depression and Anxiety

journal-article

Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study

Depression and Anxiety

journal-article

Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans

Nature Neuroscience

journal-article

Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans

Nature Neuroscience

journal-article

Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs

Molecular Psychiatry

journal-article

Precision medicine for suicidality: from universality to subtypes and personalization.

Molecular psychiatry

journal-article

Precision medicine for suicidality: From universality to subtypes and personalization

Molecular Psychiatry

journal-article

Mood, stress and longevity: convergence on ANK3.

Molecular psychiatry

journal-article

Mood, stress and longevity: Convergence on ANK3

Molecular Psychiatry

journal-article

Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment.

Molecular psychiatry

journal-article

Towards understanding and predicting suicidality in women: Biomarkers and clinical risk assessment

Molecular Psychiatry

journal-article

Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach.

Molecular psychiatry

journal-article

Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach

Molecular Psychiatry

journal-article

Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions.

Molecular psychiatry

journal-article

Psychiatric blood biomarkers: Avoiding jumping to premature negative or positive conclusions

Molecular Psychiatry

journal-article

Genetic risk prediction and neurobiological understanding of alcoholism.

Translational psychiatry

journal-article

Erratum: Genetic risk prediction and neurobiological understanding of alcoholism (Translational Psychiatry (2014) 4 (e391) DOI:10.1038/tp.2014.29)

Translational Psychiatry

journal-article

Genetic risk prediction and neurobiological understanding of alcoholism.

Translational psychiatry

journal-article

Genetic risk prediction and neurobiological understanding of alcoholism

Translational Psychiatry

journal-article

Discovery and validation of blood biomarkers for suicidality.

Molecular psychiatry

journal-article

Discovery and validation of blood biomarkers for suicidality

Molecular Psychiatry

journal-article

Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction.

Molecular psychiatry

journal-article

Convergent functional genomics of schizophrenia: From comprehensive understanding to genetic risk prediction

Molecular Psychiatry

journal-article